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KMID : 0363620070280020200
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 2 p.200 ~ p.204
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Acute Toxicity Study on Sagunja-tang(Sijunzi-tang) in ICR Mice
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Ma Jin-Yeul
Hwang Dae-Sun
Yu Young-Beob
Ha Hye-Kyung
Shin Hyun-Kyu
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Abstract
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Objective : The purpose of this study was to investigate acute toxicity of orally-treated Sagunja-tang(Sijunzi-tang) in ICR mice.
Methods : In this study, we investigated the acute toxicity of water-extracted Sagunja-tang(Sijunzi-tang). Twenty-five mice completed 14 days of oral Sagunja-tang(Sijunzi-tang) at respective doses of 0 (control group), 2560, 3200, 4000 and 5000 mg/kg.
Results : We observed survival rates, clinical signs of male ICR mice with acute toxicity, change of body weight and autopsy.
Conclusion : Compared with the control group, we could not find any toxic alteration in anytreated groups (2560, 3200, 4000 and 5000mg/kg). LD50 of Sagunja-tang(Sijunzi-tang) was over 5000 mg/kg and it is very safe for ICR mice.
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KEYWORD
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Sagunja-tang(Sijunzi-tang), acute toxicity, safety, LD50
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